General Relativity and Quantum Mechanics are at polar odds with each other, and many physicists are trying to reconcile them in a grand unified theory. Perhaps they are not meant to be unified. Maybe unity is found elsewhere.
Consciousness may be the "inner" experiential (spiritual) side of the "outer" material (physical) cosmos, these being two irreducible aspects of One thing.
Humans want to know what's real, what's reality, what's true. We have explored the outside world and our inner worlds for millennia, and we seem to still not be sure what is absolutely real. I think the issue might be that what is really real is not something that can be seen or communicated through language at our dualistic level of perception. We have to transcend duality experientially and consciously in order to know the "really real," sometimes called the Nondual, the One, the Real, the Absolute, or God. Perhaps only at that level of consciousness may we come to truly know what is ultimately Real and True.